The guardians of inherited oncogenic vulnerabilities.
Identifieur interne : 001576 ( Main/Exploration ); précédent : 001575; suivant : 001577The guardians of inherited oncogenic vulnerabilities.
Auteurs : Audrey Arnal [France] ; Tazzio Tissot [France] ; Beata Ujvari [Australie] ; Leonard Nunney [États-Unis] ; Eric Solary [France] ; Lucie Laplane [France] ; François Bonhomme [France] ; Marion Vittecoq [France] ; Aurélie Tasiemski [France] ; François Renaud [France] ; Pascal Pujol [France] ; Benjamin Roche [France] ; Frédéric Thomas [France]Source :
- Evolution; international journal of organic evolution [ 1558-5646 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Carcinogenèse.
- Animaux, Aptitude génétique, Humains, Hérédité, Mutation, Sélection génétique, Évolution biologique.
English descriptors
- KwdEn :
- MESH :
- genetics : Carcinogenesis.
- Animals, Biological Evolution, Genetic Fitness, Heredity, Humans, Mutation, Selection, Genetic.
Abstract
Similar to seemingly maladaptive genes in general, the persistence of inherited cancer-causing mutant alleles in populations remains a challenging question for evolutionary biologists. In addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. We propose that although natural defenses evolve to prevent neoplasm formation and progression thus increasing organismal fitness, they also conceal the effects of cancer-causing mutant alleles on fitness and concomitantly protect inherited ones from purging by purifying selection. We also argue for the importance of the ecological contexts experienced by individuals and/or species. These contexts determine the locally predominant fitness-reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcomes.
DOI: 10.1111/evo.12809
PubMed: 26519218
Affiliations:
- Australie, France, États-Unis
- Californie, Languedoc-Roussillon, Occitanie (région administrative), Île-de-France
- Montpellier, Orsay
- Université Montpellier 2, Université Paris-Sud
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002413
- to stream PubMed, to step Curation: 002367
- to stream PubMed, to step Checkpoint: 002367
- to stream Ncbi, to step Merge: 002C98
- to stream Ncbi, to step Curation: 002C98
- to stream Ncbi, to step Checkpoint: 002C98
- to stream Main, to step Merge: 001571
- to stream Main, to step Curation: 001576
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The guardians of inherited oncogenic vulnerabilities.</title>
<author><name sortKey="Arnal, Audrey" sort="Arnal, Audrey" uniqKey="Arnal A" first="Audrey" last="Arnal">Audrey Arnal</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France. au.arnal@gmail.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn, Ponds, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn, Ponds</wicri:regionArea>
<wicri:noRegion>Ponds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nunney, Leonard" sort="Nunney, Leonard" uniqKey="Nunney L" first="Leonard" last="Nunney">Leonard Nunney</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, University of California, Riverside, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Biology, University of California, Riverside</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Solary, Eric" sort="Solary, Eric" uniqKey="Solary E" first="Eric" last="Solary">Eric Solary</name>
<affiliation wicri:level="4"><nlm:affiliation>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laplane, Lucie" sort="Laplane, Lucie" uniqKey="Laplane L" first="Lucie" last="Laplane">Lucie Laplane</name>
<affiliation wicri:level="4"><nlm:affiliation>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonhomme, Francois" sort="Bonhomme, Francois" uniqKey="Bonhomme F" first="François" last="Bonhomme">François Bonhomme</name>
<affiliation wicri:level="4"><nlm:affiliation>ISEM Institut des sciences de l'évolution, Université Montpellier 2, CNRS, Montpellier Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ISEM Institut des sciences de l'évolution, Université Montpellier 2, CNRS, Montpellier Cedex</wicri:regionArea>
<wicri:noRegion>Montpellier Cedex</wicri:noRegion>
<orgName type="university">Université Montpellier 2</orgName>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vittecoq, Marion" sort="Vittecoq, Marion" uniqKey="Vittecoq M" first="Marion" last="Vittecoq">Marion Vittecoq</name>
<affiliation wicri:level="1"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tasiemski, Aurelie" sort="Tasiemski, Aurelie" uniqKey="Tasiemski A" first="Aurélie" last="Tasiemski">Aurélie Tasiemski</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, 59000 Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, 59000 Lille</wicri:regionArea>
<wicri:noRegion>59000 Lille</wicri:noRegion>
<wicri:noRegion>59000 Lille</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name>
<affiliation wicri:level="1"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de génétique médicale et chromosomique, Unité d'oncogénétique, CHRU de Montpellier, Hôpital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de génétique médicale et chromosomique, Unité d'oncogénétique, CHRU de Montpellier, Hôpital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295, Montpellier</wicri:regionArea>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26519218</idno>
<idno type="pmid">26519218</idno>
<idno type="doi">10.1111/evo.12809</idno>
<idno type="wicri:Area/PubMed/Corpus">002413</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002413</idno>
<idno type="wicri:Area/PubMed/Curation">002367</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002367</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002367</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002367</idno>
<idno type="wicri:Area/Ncbi/Merge">002C98</idno>
<idno type="wicri:Area/Ncbi/Curation">002C98</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002C98</idno>
<idno type="wicri:Area/Main/Merge">001571</idno>
<idno type="wicri:Area/Main/Curation">001576</idno>
<idno type="wicri:Area/Main/Exploration">001576</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The guardians of inherited oncogenic vulnerabilities.</title>
<author><name sortKey="Arnal, Audrey" sort="Arnal, Audrey" uniqKey="Arnal A" first="Audrey" last="Arnal">Audrey Arnal</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France. au.arnal@gmail.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn, Ponds, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn, Ponds</wicri:regionArea>
<wicri:noRegion>Ponds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nunney, Leonard" sort="Nunney, Leonard" uniqKey="Nunney L" first="Leonard" last="Nunney">Leonard Nunney</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, University of California, Riverside, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Biology, University of California, Riverside</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Solary, Eric" sort="Solary, Eric" uniqKey="Solary E" first="Eric" last="Solary">Eric Solary</name>
<affiliation wicri:level="4"><nlm:affiliation>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laplane, Lucie" sort="Laplane, Lucie" uniqKey="Laplane L" first="Lucie" last="Laplane">Lucie Laplane</name>
<affiliation wicri:level="4"><nlm:affiliation>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1009, Université Paris-Sud, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonhomme, Francois" sort="Bonhomme, Francois" uniqKey="Bonhomme F" first="François" last="Bonhomme">François Bonhomme</name>
<affiliation wicri:level="4"><nlm:affiliation>ISEM Institut des sciences de l'évolution, Université Montpellier 2, CNRS, Montpellier Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ISEM Institut des sciences de l'évolution, Université Montpellier 2, CNRS, Montpellier Cedex</wicri:regionArea>
<wicri:noRegion>Montpellier Cedex</wicri:noRegion>
<orgName type="university">Université Montpellier 2</orgName>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vittecoq, Marion" sort="Vittecoq, Marion" uniqKey="Vittecoq M" first="Marion" last="Vittecoq">Marion Vittecoq</name>
<affiliation wicri:level="1"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tasiemski, Aurelie" sort="Tasiemski, Aurelie" uniqKey="Tasiemski A" first="Aurélie" last="Tasiemski">Aurélie Tasiemski</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, 59000 Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, 59000 Lille</wicri:regionArea>
<wicri:noRegion>59000 Lille</wicri:noRegion>
<wicri:noRegion>59000 Lille</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name>
<affiliation wicri:level="1"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de génétique médicale et chromosomique, Unité d'oncogénétique, CHRU de Montpellier, Hôpital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de génétique médicale et chromosomique, Unité d'oncogénétique, CHRU de Montpellier, Hôpital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295, Montpellier</wicri:regionArea>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<wicri:noRegion>34394, Montpellier Cedex 5</wicri:noRegion>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name>
<affiliation wicri:level="3"><nlm:affiliation>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CREEC, MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Evolution; international journal of organic evolution</title>
<idno type="eISSN">1558-5646</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biological Evolution</term>
<term>Carcinogenesis (genetics)</term>
<term>Genetic Fitness</term>
<term>Heredity</term>
<term>Humans</term>
<term>Mutation</term>
<term>Selection, Genetic</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Aptitude génétique</term>
<term>Carcinogenèse (génétique)</term>
<term>Humains</term>
<term>Hérédité</term>
<term>Mutation</term>
<term>Sélection génétique</term>
<term>Évolution biologique</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinogenèse</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biological Evolution</term>
<term>Genetic Fitness</term>
<term>Heredity</term>
<term>Humans</term>
<term>Mutation</term>
<term>Selection, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Aptitude génétique</term>
<term>Humains</term>
<term>Hérédité</term>
<term>Mutation</term>
<term>Sélection génétique</term>
<term>Évolution biologique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Similar to seemingly maladaptive genes in general, the persistence of inherited cancer-causing mutant alleles in populations remains a challenging question for evolutionary biologists. In addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. We propose that although natural defenses evolve to prevent neoplasm formation and progression thus increasing organismal fitness, they also conceal the effects of cancer-causing mutant alleles on fitness and concomitantly protect inherited ones from purging by purifying selection. We also argue for the importance of the ecological contexts experienced by individuals and/or species. These contexts determine the locally predominant fitness-reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcomes.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Montpellier</li>
<li>Orsay</li>
</settlement>
<orgName><li>Université Montpellier 2</li>
<li>Université Paris-Sud</li>
</orgName>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Arnal, Audrey" sort="Arnal, Audrey" uniqKey="Arnal A" first="Audrey" last="Arnal">Audrey Arnal</name>
</region>
<name sortKey="Bonhomme, Francois" sort="Bonhomme, Francois" uniqKey="Bonhomme F" first="François" last="Bonhomme">François Bonhomme</name>
<name sortKey="Laplane, Lucie" sort="Laplane, Lucie" uniqKey="Laplane L" first="Lucie" last="Laplane">Lucie Laplane</name>
<name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name>
<name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name>
<name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name>
<name sortKey="Solary, Eric" sort="Solary, Eric" uniqKey="Solary E" first="Eric" last="Solary">Eric Solary</name>
<name sortKey="Tasiemski, Aurelie" sort="Tasiemski, Aurelie" uniqKey="Tasiemski A" first="Aurélie" last="Tasiemski">Aurélie Tasiemski</name>
<name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name>
<name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name>
<name sortKey="Vittecoq, Marion" sort="Vittecoq, Marion" uniqKey="Vittecoq M" first="Marion" last="Vittecoq">Marion Vittecoq</name>
</country>
<country name="Australie"><noRegion><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Nunney, Leonard" sort="Nunney, Leonard" uniqKey="Nunney L" first="Leonard" last="Nunney">Leonard Nunney</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001576 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001576 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:26519218 |texte= The guardians of inherited oncogenic vulnerabilities. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26519218" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |